世界*实验材料供应商 Dianova 正式授权上海起发为其中国代理， Dianova 在一直是行业的*,一直为广大科研客户提供zui为的产品和服务,上海起发一直秉承为中国科研客户带来的产品，的服务，签约 Dianova 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获

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Dianova公司为德国的病理免疫组化产品供应商，具备的抗体制备工艺及严格的质控系统，产品在上享有良好的声誉。

克隆号为H09的IDH1（isocitrate dehydrogenase 1, 异柠檬酸盐脱氢酶1）鼠单克隆抗体为Dianova公司近期推出的产品之一，此抗体可特异性的检测脑组织肿瘤中IDH1基因的R132H点突变。IDH1基因的第132密码子的杂合突变是II 和III级神经胶质瘤（根据WHO的肿瘤学分类）的频发事件。在大约70％的星形胶质细胞瘤和少突神经胶质细胞瘤可发现IDH1基因的R132H点突变。

IDH1基因R132H突变在部分脑肿瘤中的频发现象使克隆号为H09的IDH1抗体可高灵敏性和高特异性的用于此类肿瘤的鉴别诊断中：如从原发性胶质母细胞瘤中区分出间变性星形细胞瘤、从毛细胞型星形细胞瘤或室管膜（细胞）瘤中区分出弥漫性星形细胞瘤（WHO分类II级），也可以用于具有IDH1突变的肿瘤细胞浸润前沿的与反应性神经胶质增多症的区分。因此，由于其高灵敏性和高特异性，此抗体在脑部肿瘤的分类分级中以及在检测单一或少量浸润肿瘤细胞时是非常有用的。

DIA-310-M – Anti-CD31 (Ms) aus Ratte (Klon: SZ31) für Paraffingewebe aus Maus – 100 µl

Art.-Nr.                             DIA-310-M

Spezifität                           CD31 (PECAM-1)

Spezies-Reaktivität                  Schwein

                                     Maus

Wirtsspezies                         Ratte

Isotyp                               IgG2a

Klon                                  SZ31

Klonalität (Mono-/Polyklonal)         monoklonal

Anwendung                            Immunhistochemie (IHC)

                                     Immunhistochemie (Paraffingewebe)
                                     Gefrierschnitte (IHC-F)
                                     Western Blot

Konjugation                          unkonjugiert

Format                               Lyophilisat

                                     gereinigter Antikörper (aus Kulturüberstand)

Produktlinie / Thema                 Angiogenese

                                     CD-Marker
                                     Immunhistochemie

Zweckbestimmung                      nur für Forschungszwecke

Suchcode                             DIA310M

                                     FFPE
                                     Paraffin

Hersler / Marke                   dianova

Reactivity

Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.
CD31, also known as PECAM-1 (Plaet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, plaets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells.CD31 is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.

Immunohistochemistry of mouse CD31 (PECAM-1) in formalin-fixed paraffin-embedded tissue sections

The monoclonal antibody clone SZ31 reacts specifically with endothelial cells in vessels and capillaries of:

aorta

aortic origin

endocardium

small intestine

small intestine

colon

brain

lymph nodes

bone marrow

mesenterial vessels

kidney

pancreas

(pictures courtesy of Prof. Dr. Robert Klopfleisch, Institute of Pathology, Department of Veterinary Pathology, Berlin, Germany)

Lung

Muscle

Spinal

Liver

Adenocarcinoma

Adenocarcinoma

(pictures courtesy of Prof.Dr.H.Stein, Institute of Pathology, Charité Campus Benjamin Franklin, Berlin, Germany)

Western blot analysis

Immunoblot of extracts from murine lung, J558L cells and m-Lend cells using CD31 rat monoclonal antibody clone SZ31 (DIA-310 1:5.000) and goat anti-rat-HRP antibody (1:10.000).

Lane:

1. J558 cells (CD31-), 25μg lysate
2. murine lung, 25μg lysate
3. blank
4. m-Lend cells (CD31+), 12.5μg lysate

References

1. Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A.
   Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
   J.Biol.Chem. 286: 11185-11194, 2011
2. Kröger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM. Placental vasculogenesis is
   regulated by keratin-mediated hyperoxia in murine decidual tissues. Am.J.Pathol. 178(4): 1587-1590, 2011
3. Jiang J, Thyagarajan-Sahu A, Krchnák V, Jedinak A, Sandusky GE, et al. NAHA, a Novel Hydroxamic Acid-Derivative,
   Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. PLoS ONE 7(3): e34283, 2012
4. Copeland BT, Bowman MJ, Ashman LK. Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic
   Spread of Prostate Cancer in the TRAMP Model. Mol Cancer Res. 11(1):95-105, 2013
5. Agliano A, Martin-Padura I, Marighetti P, Gregato G, Calleri A, Prior C, Redrado M, Calvo A, Bertolini F. Therapeutic effect
   of lenalidomide in a novel xenograft mouse model of human blastic NK cell lymphoma/blastic plasmacytoid dendritic
   cell neoplasm. Clin Cancer Res. 1;17(19):6163-73, 2011
6. Ferretti E, Montagna D, Di Carlo E, Cocco C, Ribatti D, Ognio E, Sorrentino C, Lisini D, Bertaina A, Locali F, Pistoia V,
   Airoldi I. Absence of IL-12Rβ2 in CD33(+)CD38(+) pediatric acute myeloid leukemia cells favours progression in
   NOD/SCID/IL2RϒC-deficient mice. Leukemia 26(2):225-35,2012

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