list biological laboratories公司是世界的科研毒素试剂供应商，其毒素包括霍乱病毒，蛇毒，百日咳毒素等各类毒素,我公司常年低价供应,货期快.有意者请. 百日咳毒素长期现货供应，货号181及180。
list biological 758A
一种主要的医院病原体，艰难梭菌（Clostridium difficile）引起抗生素相关性结肠炎和肠道炎症性疾病，一起称为CDI。
C艰难梭菌毒素如何引起腹泻？ 通过释放两种大蛋白肠毒素，艰难梭菌毒素A（TcdA）和艰难梭菌毒素B（TcdB），艰难梭菌介导炎性腹泻并损害肠上皮细胞。施用于培养细胞时的毒素都会破坏细胞骨架并引发细胞凋亡依赖性细胞凋亡，尽管艰难梭菌毒素B的效力比艰难梭菌多很多倍。毒素A.两种毒素还激活肠上皮细胞和免疫细胞以产生细胞因子和趋化因子，可能导致与严重CDI相关的并发症。TcdA和TcdB的细胞内靶标是RhoGTP酶，其调节许多宿主细胞过程，包括建立上皮屏障和免疫细胞的迁移和信号传导。当Rho蛋白被艰难梭菌毒素A或B 糖基化时，信号被破坏，导致CDI的肠损伤和炎症特征。
List Labs C. Difficile Toxins参与了诊断的研究和开发。
抗艰难梭菌二元毒素B亚基（鸡lgY）
产品＃和尺寸
＃758A（0.1毫克） - 320.00美元
艰难梭菌是引起抗生素相关性腹泻和假膜性大肠杆菌的病原体。
1，2它产生两种主要的外毒素(毒素A和毒素B)。
大型梭状细胞毒素科。一些艰难梭菌还产生一种二价ADP-核糖化毒素(CDT)，这种毒素可以修饰actin3 CDT二元毒素在疾病诱导中的致病作用 艰难梭菌的ED尚不清楚，但从结肠炎患者中分离出的约10%的菌株含有CDT二元毒素基因。
4，5艰难梭菌A和B为高分子量葡糖基转运体。 抑制GTPases Rho家族成员的rase。毒素A被称为肠毒素，分子量为300 kDa，等电点为5.3。毒素B，被称为细胞毒素， 分子量为270 kDa，pl为4.1。毒素A和毒素B通过苏氨酸残基的葡萄糖化使Rho、RAC和Cdc 42等小GTPase失活。6，7，8抑制这些GTPase S导致信号转导级联的关闭，导致细胞骨架的解聚，某些应激激活蛋白激酶的基因转录，磷脂合成的下降。
Ylinositol 4，5二磷酸甚至可能导致细胞极化的丧失9细胞骨架结构的丧失导致细胞的四舍五入，这种结构的丧失可能是宿主对C的反应的原因。 艰难。毒素A和B所针对的GTP酶与许多细胞反应有关，但这些毒素具有不同的生理效应。这两种毒素都会刺激皮肤，增加维生素A。 [10]只有毒素A在上皮细胞表面有一个结合位点，即碳水化合物11，这可能与兔回肠的剧烈反应有关。23，
13毒素B是一种p型毒素。 组织培养中哺乳动物细胞的细胞毒素14，
15毒素B在细胞四舍五入中的毒性至少是毒素A的1000倍。通过抑制信号转导级联，毒素A 毒素B可以阻断下游的反应。毒素A可诱导白介素8.
16毒素B可能阻断5-羟色胺的释放，
17以及刺激磷脂的产生 ESC和D.
18，19由于具有影响细胞骨架解聚的能力，毒素B被证明能抑制双相肌肉收缩。
20艰难梭菌毒素A和B有63%的同源性。 每种毒素的C-末端第三位都是由被称为梭状重复寡肽(作物)的高度序列组成。 Y抗原。其余的N端三分之二的毒素A和B在序列同源性方面不太相似，但每种蛋白质的这一部分都含有葡萄糖。
22，23 CDT二元毒素是ADP-核糖转移酶家族(ADPRT)的成员。3 CDT二元毒素与C.肉毒杆菌C2毒素同属于AB二元毒素亚家族。 产气荚膜的毒素。
24该二元毒素由两个独立产生的组分组成，即酶组分A亚基CdtA(48 KD)和结合和易位复合物。 Nent B亚基CdtB(94 KD)介导CdtA细胞的进入。
25 cdt二元毒素引起肌动蛋白细胞骨架的解聚和微管基膜突起的形成。
[26]CDT二价毒素B亚基cdtB是cdtA进入TH的必需物质。26 CDT二进毒素cdtB亚基cdtB参与了高致病性艰难梭菌的粘附和定植。
27 CdtB组分必须通过切割激活，然后在细胞表面形成七肽，并与特定的细胞表面受体结合。细胞表面受体已被识别 28随后，CdtA与CdtB结合，通过受体介导的内吞作用进入细胞。cdtA的N端与INTERA有关。 在cdtB作用下，C端含有酶活性。29根据lota毒素的活性，预测cdp-核糖单聚体G-actin在arg 17上将不可逆转。 7残留。这种ADP-核糖基化将阻止G-肌动蛋白与F-肌动蛋白的聚合，破坏F-actin：G-actin的平衡，从而导致细胞的四舍五入和细胞死亡。
产品仅用于研究目的，不用于人类或诊断剂。
货号 | 品名 | 规格 | 价格 |
list104 | Cholera Toxin B Subunit (Choleragenoid) in low salt1 | 0.5mg | 4930 |
list106 | Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC) | 0.2mg | 9775 |
list112 | Cholera Toxin B Subunit Biotin | 0.2mg | 9775 |
list122 | Enterotoxin Type B from Staphylococcus aureus1,3 | 0.5mg | 7225 |
list123 | Enterotoxin Type B Toxoid from Staphylococcus aureus 1,3 | 0.25mg | 8075 |
list139 | Botulinum Neurotoxin Type B Toxoid | 10µg | 6800 |
list150 | Diphtheria Toxin, unnicked from Corynebacterium diphtheriae | 1mg | 11050 |
list151 | Diphtheria Toxoid, from Corynebacterium diphtheriae | 0.5mg | 10625 |
list153 | Toxin A Toxoid from Clostridium difficile | 100µg | 11900 |
list156 | Pasteurella Multocida Toxin | 50µg | 8075 |
list160 | Exotoxin A from Pseudomonas aeruginosa | 1mg | 4420 |
list161 | Shiga Toxin 1 from Escherichia coli1,4,8 | 10µg | 11900 |
list162 | Shiga Toxin 2 from Escherichia coli1,4,8 | 10µg | 11050 |
list174 | Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis | 0.5mg | 9350 |
list175 | Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC) | 50µg | 7225 |
list180 | Pertussis Toxin Islet-Activating Protein Lyophilized in buffer | 50µg | 5525 |
list181 | Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free) | 50µg | 5525 |
list184 | Pertussis Toxin Mutant | 50µg | 5525 |
list186 | FIMBRIAE 2/3 from B. pertussis | 50µg | 5950 |
list187 | Pertactin from Bordetella pertussus (69 kDa Protein) | 50µg | 4590 |
list193 | Tetanus Toxin C Fragment | 10µg | 9350 |
list201 | LPS from Escherichia coli O111:B4 | 5mg | 3230 |
list206 | LPS, Escherichia coli 0157:H7 | 10.0mg | 4760 |
list225 | LPS from Salmonella typhimurium | 5mg | 2890 |
list301 | LPS from Escherichia coli J5 (Rc) | 5mg | 2890 |
list302 | LPS from Escherichia coli K12, D31m4 (Re) | 5mg | 2890 |
list304 | LPS from Salmonella minnesota R595 (Re) | 5mg | 2890 |
list314 | LPS from Escherichia coli K12 strain LCD25 | 1mg | 2890 |
list400 | HPT™ LPS, highly purified from Bordetella Pertussis 165 | 1mg | 5100 |
list401 | Lipid A monophosphoryl from Salmonella minnesota R595 | 1mg | 3400 |
list421 | Ultra Pure LPS from Escherichia coli O111:B4 | 1mg | 3570 |
list423 | Ultra Pure LPS from Escherichia coli O55:B5 | 1mg | 3570 |
list433 | LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS | 1mg | 4080 |
list434 | Ultra Pure LPS from Salmonella minnesota R595 (Re) | 1mg | 3400 |
list520 | SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006) | 200nmoles | 9775 |
list521 | SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006) | 200nmoles | 8500 |
list523 | SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675 | 200nmoles | 8500 |
list525 | Control Peptide for SNAPtideÒ #520 | 200nmoles | 8500 |
list526 | Control Peptide for SNAPtide® #521 | 200nmoles | 8500 |
list528 | Unquenched Calibration Peptide for SNAPtide® 521 | 50nmoles | 2890 |
list529 | Unquenched Calibration Peptide for SNAPtide® 520 | 50nmoles | 2890 |
list530 | MAPKKide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 5100 |
list531 | MAPKKide® Peptide Substrate (DABCYL/FITC) | 200nmoles | 5100 |
list532 | MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor | 100nmoles | 4250 |
list539 | Unquenched Calibration Peptide for MAPKKideÒ 530 | 50nmoles | 2890 |
list540 | VAMPtide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 8500 |
list541 | VAMPtide® Peptide Substrate (FITC/DABCYL) | 200nmoles | 8500 |
list542 | VAMPtide® Peptide Substrate (PL 150, Pya/Nop) | 200nmoles | 8500 |
list549 | Calibration Fluorophore for VAMPtideÒ 540 | 100nmoles | 2890 |
list550 | SNAP Etide® Peptide Substrate (o-Abz/Dnp) | 100nmoles | 6800 |
list560 | SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C | 200nmoles | 8500 |
list703 | Anti-Cholera Toxin B Subunit (Goat) | 0.1ml | 3060 |
list752 | Anti-Toxin A from Clostridium difficile (Goat) | 0.5ml | 3230 |
list760 | Anti-Exotoxin A (Goat) | 0.5ml | 3400 |
list781 | Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7 | 0.1mg | 7055 |
list100B | Cholera Toxin (Azide Free)1 | 1mg | 3400 |
list101B | Cholera Toxin1 | 1mg | 3400 |
list101C | Cholera Toxin1 | 2mg | 5355 |
list116L | Alpha Toxin from C. septicum4,6,7 | 50µg | 4930 |
list126A | Epsilon Toxin from C. perfringens1,4,8 | 0.1mg | 5950 |
list128A | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list128C | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 100µg | 5440 |
list130A | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 10µg | 5440 |
list130B | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 100µg | 13600 |
list133L | Botulinum Neurotoxin Type A Toxoid, Liquid6,7 | 10µg | 5440 |
list136A | Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3 | 10µg | 5100 |
list136B | Botulinum Neurotoxin Type B, from Clostridium botulinum1,3 | 100µg | 17000 |
list138A | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 10µg | 2890 |
list138B | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 100µg | 7225 |
list140A | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list140B | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 100µg | 8925 |
list141A | Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3 | 10µg | 8075 |
list146A | Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3 | 10µg | 5355 |
list149A | Diphtheria Toxin CRM Mutant | 0.25 mg | 8500 |
list152C | Toxin A from Clostridium difficile | 100µg | 9010 |
list154A | Toxin B Toxoid from Clostridium difficile | 20µg | 2890 |
list15 | Toxin B from Clostridium difficile | 2µg | 2890 |
list155B | Toxin B from Clostridium difficile | 20µg | 8500 |
list155C | Toxin B from Clostridium difficile | 200µg | 15300 |
list155L | Toxin B from Clostridium difficile, Liquid6,7 | 50µg | 9860 |
list157A | Binary Toxin from Clostridium difficile, A Subunit | 20µg | 5950 |
list158A | Binary Toxin from Clostridium difficile, B Subunit | 40µg | 5950 |
list159A | Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7 | 0.1mg | 4930 |
list169A | Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence | 0.1mg | 3060 |
list169B | Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence | 1mg | 12750 |
list169L | Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7 | 0.2 mg | 5950 |
list171E | Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis | 0.5mg | 8755 |
list172B | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 1mg | 12750 |
list172C | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 10mg | 39525 |
list172L | Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7 | 1.0 mg | 12750 |
list173B | Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis | 0.5mg | 16150 |
list176A | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 0.1mg | 5100 |
list176B | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 1mg | 16150 |
list177A | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 50µg | 5950 |
list177B | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 0.25mg | 11050 |
list178A | Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis | 0.1mg | 2890 |
list179A | Pertussis Toxin Islet Activating Protein (in glycerol)6,7 | 50µg | 4845 |
list188L | Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7 | 50µg | 5270 |
list190A | Tetanus Toxin2 | 25µg | 2890 |
list190B | Tetanus Toxin2 | 100µg | 9350 |
list191A | Tetanus Toxoid | 25µg | 4675 |
list191B | Tetanus Toxoid | 100µg | 13600 |
list196A | C-fragment, FITC Conjugate | 10µg | 6800 |
list203A | LPS, Escherichia coli O55:B5 | 2.5 mg | 3060 |
list500A | SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin | 100µg | 5525 |
list510A | GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F | 100µg | 5950 |
list610A | Botulinum Neurotoxin Type A Light Chain, Recombinant1 | 10µg | 4760 |
list611A | Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1 | 15µg | 4760 |
list612A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list613A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list620A | Botulinum Neurotoxin Type B Light Chain, Recombinant1 | 10µg | 8500 |
list622A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list623A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list62 | Botulinum Neurotoxin Type C Light Chain, Recombinant1 | 10µg | 8500 |
list630A | Botulinum Neurotoxin Type D Light Chain, Recombinant1 | 10µg | 5695 |
list650A | Tetanus Toxin Light Chain, Recombinant | 10µg | 3825 |
list690B | Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain | 100nmoles | 6800 |
list730A | Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7 | 0.1mg | 5610 |
list731L | Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7 | 0.1mg | 5950 |
list736A | Anti-Botulinum Type B (Chicken lgY), Liquid6,7 | 0.1mg | 5950 |
list753A | Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list754A | Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list756A | Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7 | 0.1mg | 5780 |
list757A | Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list758A | Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list759A | Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list761L | Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7 | 0.5mg | 3400 |
list765L | Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7 | 0.5mg | 2890 |
list766L | Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7 | 0.5mg/ml | 5950 |
list768L | Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7 | 0.1mg | 5950 |
list769B | Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7 | 0.2mg | 8500 |
list771B | Anti-Protective Antigen from Bacillus anthracis (Goat) | 1mg | 2890 |
list772B | Anti-Lethal Factor from Bacillus anthracis (Goat) | 1.0 mg | 2890 |
list773L | Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7 | 1mg | 2890 |
Listlabs中国代理,Listlabs上海代理，Listlabs北京代理，Listlabs广东代理，Listlabs江苏代理Listlabs湖北代理,Listlabs天津代理,Listlabs黑龙江代理,Listlabs湖南代理Listlabs内蒙古代理,Listlabs吉林代理,Listlabs福建代理,Listlabs江苏代理,Listlabs浙江代理,Listlabs四川代理,Listlabs代理，
上海起发实验试剂有限公司是实验试剂一站式采购服务商
1：强大的进口辐射能力，血清、抗体、耗材、大部分限制进口品等。
2：产品种类齐全，经营超过700多品牌，基本涵盖所有生物实验试剂耗材。
3：提供加急服务，货品一般1-2周到货。
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