现货moradec AH-106-PB说明书
αHFc CL PBD
抗人IgG Fc PBD抗体与可裂解连接子
目录号：AH-106-PB
αHFc CL PBD是抗人IgG Fc特异性抗体，与吡咯并二氮杂平（PBD）通过可裂解接头偶联。抗体部分是对人IgG的Fc区特异的多克隆抗体。吡咯并二氮卓（PBD）是一种细胞毒性小分子，它与DNA小凹槽结合，并与DNA的特定位点交叉连接。连接PBD和抗体的可裂解接头在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，就会被内体中的组织蛋白酶裂解。
| Anti-human IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AH-106-PB |
| αHFc-CL-PBD is anti-human IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
