现货moradec AM-106-PB说明书
αMFc CL PBD
具有可裂解连接子的抗小鼠IgG Fc PBD抗体
目录号：AM-106-PB
αMFc CL PBD是抗小鼠IgG Fc特异性抗体，与吡咯并二氮杂平（PBD）结合，具有可裂解接头。抗体部分是对小鼠IgG的Fc区具有特异性的多克隆抗体，并且它也对大鼠IgG的Fc区具有交叉反应性。吡咯并二氮卓（PBD）是一种细胞毒性小分子，它与DNA小凹槽结合，并与DNA的特定位点交叉连接。连接PBD和抗体的可裂解接头在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，就会被内体中的组织蛋白酶裂解。
| Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker | Catalog Number: AM-106-PB |
| αMFc-CL-PBD is anti-mouse IgG Fc specific antibody conjugated to pyrrolobenzodiazepine (PBD) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs, and it is also cross-reactive to the Fc region of Rat IgGs. Pyrrolobenzodiazepine (PBD) is a cytotoxic small molecule which binds to DNA minor groove and cross-links specific sites of DNA. The cleavable linker connecting PBD to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
