现货moradec AH-102-DD说明书
αHFc CL PNU
抗人IgG Fc-PNU159682抗体
目录号：AH-102-DD
αHFc CL PNU是与PNU-159268结合的抗人IgG Fc特异性抗体，具有可裂解接头。抗体部分是对人IgG的Fc区特异的多克隆抗体。PNU-159682是内柔比星的衍生物，是一种细胞毒性小分子，通过插入DNA和抑制复制导致细胞死亡。连接PNU-159682与抗体的可裂解接头在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，则被内体中的组织蛋白酶裂解。
| Anti-human IgG Fc-PNU159682 Antibody with Cleavable Linker | Catalog Number: AH-102-DD |
| αHFc-CL-PNU is anti-human IgG Fc specific antibody conjugated to PNU-159268 with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. PNU-159682, a derivative of nemorubicin, is a cytotoxic small molecule which causes cell death by intercalating DNA and inhibiting replication. The cleavable linker connecting PNU-159682 to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis. | |
