现货moradec AH-207-DX说明书
Fab-αHFc-CL-DX8951
Fab抗人IgG Fc-DX9851抗体
目录号：AH-207-DX
Fab-αHFc-CL-DX8951是抗人IgG Fc特异性抗体的Fab片段，与甲磺酸艾替康（DX8951）结合，具有可裂解的接头。抗体部分是对人IgG的Fc区特异的多克隆抗体Fab片段。甲磺酸埃克替康（DX8951）是一种拓扑异构酶I抑制剂。连接DX8951和抗体的可裂解接头（GGFG）在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，就会在内体中被裂解。Fab 2°ADC的单价性质在某些应用中可能比全长IgG 2°ADC具有一些优势。
| Fab Anti-Human IgG Fc-DX9851 Antibody with Cleavable Linker | Catalog Number: AH-207-DX |
| Fab-αHFc-CL-DX8951 is a Fab fragment of anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC. | |
