现货moradec AH-107-DX说明书

现货moradec AH-107-DX说明书

αHFc-CL-DX8951

抗人IgG Fc-DX8951抗体与可裂解连接子

目录号：AH-107-DX

αHFc-CL-DX8951是一种抗人IgG Fc特异性抗体，与甲磺酸埃克替康（DX8951）结合。抗体部分是对人IgG的Fc区特异的多克隆抗体。甲磺酸埃克替康（DX8951）是一种拓扑异构酶I抑制剂。连接DX8951和抗体的可裂解接头（GGFG）在细胞外液中是稳定的，但一旦缀合物通过内吞作用进入细胞，则在内体中被裂解。

αHFc-CL-DX8951

Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker	Catalog Number: AH-107-DX
αHFc-CL-DX8951 is anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.